First dissolved in DMSO (up to at least 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Tribioscience BT2, BCKDC Kinase Inhibitor (TBI4717)
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Tribioscience BT2, BCKDC Kinase Inhibitor (TBI4717)
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Product Details
Formal Name: 3,6-Dichlorobenzo[b]thiophene-2-carboxylic acid
Molecular Formula: C9H4Cl2O2S
Formula Weight: 247.10
CAS Number: 34576-94-8
Purity: >98%
Formulation: Powder
Solubility: Soluble in DMSO (up to at least 20 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
BCKDC kinase inhibitor
Functions
BT2 is an inhibitor of the mitochondrial branched-chain α-ketoacid dehydrogenase complex kinase (BCKDC) – IC50 = 3.19 µM. Inhibition of this kinase has been shown to reduce levels of branched-chain amino acid concentrations in vivo. BT2 has also been shown to be a moderate inhibitor (Ki = 59 µM) of myeloid cell leukemia 1(Mcl 1), a Bcl-2 family protein.
Application Procedures