Product Details
Formal Name: 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic acid, methyl ester, hydrobromide
Molecular Formula: C8H13NO2 HBr
Formula Weight: 236.11
CAS Number: 300-08-3
Purity: >98%
Formulation: powder
Solubility: Soluble in Water (up to 50 mg/ml).
Storage: RT
Stability: ≥ 2 years.
Applications
ACAT1 inhibitor
Functions
Tyrosine407 phosphorylation activates mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is “hijacked” and contributes to the Warburg effect in cancer. Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 μM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass. Agonist at muscarinic acetylcholine receptors M1 – M5 (EC50 in the range of 7-410 nM). May be effective in dementia.
Application Procedures
First dissolved in Water (up to 50 mg/ml), then diluted to aqueous buffer. Solutions are not stable – make fresh daily.