Cyclin D1 Monoclonal Antibody Synonyms Cyclin D1
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Cyclin D1 Monoclonal Antibody Synonyms Cyclin D1
Product Details
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC-P |
| Synonyms | Cyclin D1 |
| Cellular Localization | nucleus |
| Tissue Specificity | Tonsil |
| Storage | The RTU should be stored at 2~8°C protecting from light (Do not freeze),Valid for 12 months. |
| Shipping | Ice bag |
Background
Cyclin D1 was localized in the nucleus, and its expression was related to the cell cycle, with the highest expression in G1 phase and the lowest expression in S phase. In normal tissues, Cyclin D1 expression is restricted to the proliferative zone of epithelial tissues, endothelial cells, and some fibroblasts and is absent in lymphoid tissues. Cell cycle progression due to Cyclin D1 gene amplification and protein overexpression by mutations has been observed in a variety of cancers and may contribute to tumorigenesis. In diagnostic pathology, immunohistochemical detection of Cyclin D1 is mainly used for the diagnosis of mantle cell lymphoma.