XRCC4 Monoclonal Antibody
SKU: E-AB-22044-200
XRCC4 Monoclonal Antibody
| SKU # | E-AB-22044 |
| Reactivity | Human |
| Host | Mouse |
| Applications | WB, IHC-p, IF, IP |
Product Details
| Isotype | IgG |
| Host | Mouse |
| Reactivity | Human |
| Applications | WB, IHC-p, IF, IP |
| Clonality | Monoclonal |
| Immunogen | Synthetic Peptide |
| Abbre | XRCC4 |
| Synonyms | DNA double strand break repair and V(D)J recombination protein XRCC4, DNA repair protein XRCC4, SSMED, X ray repair complementing defective repair in Chinese hamster cells 4, X ray repair cross complementing 4, X ray repair cross complementing protein 4, X-ray |
| Swissprot | |
| Calculated MW | 38 kDa |
| Observed MW | 38 kDa |
| Cellular Localization | Nucleus. |
| Tissue Specificity | Widely expressed |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Protein A purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Clone No. | 8K2 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:50-300 |
| IF | 1:50-1:200 |
| IP | 1:100-1:300 |
Background
Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.