UMPS Polyclonal Antibody Reactivity Human
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UMPS Polyclonal Antibody Reactivity Human
| SKU # | E-AB-52440 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human UMPS |
| Abbre | UMPS |
| Synonyms | ODC, OMPdecase, OPRT, OPRTase, Orotate phosphoribosyl transferase and orotidine 5' decarboxylase, Orotate phosphoribosyltransferase, Orotate phosphoribosyltransferase phosphoribosyltransferase, Orotidine 5' phosphate decarboxylase, Orotidine 5''-phosphate decarbo |
| Swissprot | |
| Calculated MW | 52 kDa |
| Observed MW | Refer to figures |
| Concentration | 0.7 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Epigenetics and Nuclear Signaling, Metabolism |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:30-1:150 |
Background
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.