Product Details
Formal Name: 1H-β-D-ribofuranosyl-2-pyrimidinone
Alternate Names: NSC 309132
Molecular Formula: C9H12N2O5
Formula Weight: 228.21
CAS Number: 3690-10-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
DNA methylation inhibitor
Functions
Orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Inhibits cytidine deaminase (Ki ~ 2 μM); induces differentiation of mesenchymal stem cells into cardiomyocytes.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.