Tribioscience Tyrphostin 9, PDGFRK inhibitor; Oxidative Phosphorylation Inhibitor (TBI1535)

Tribioscience Tyrphostin 9, PDGFRK inhibitor; Oxidative Phosphorylation Inhibitor (TBI1535)

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Product Details

Formal Name: 3,5-Di-tert-butyl-4-hydroxybenzylidene-malononitrile

Alternate Names: Tyrphostin a9; Malonoben; AG-17; SF 6847; RG-50872

Molecular Formula: C₁₈H₂₂N₂O

Formula Weight: 282.38

CAS Number: 10537-47-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)

Storage: RT

Stability: ≥ 2 years.

Applications

PDGFRK inhibitor; Oxidative phosphorylation Inhibitor

Functions

Inhibits PDGF receptor tyrosine kinase (IC50 = 1.2 μM) and is a potent (10 nM) inhibitor of oxidative phosphorylation. Inhibits cell growth by disrupting mitochondria. Perturbs the golgi complex and blocks proliferation of vascular smooth muscle cells.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.