Product Detail
Formal Name: (3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid hydrochloride
Alternate Names: NO-325
Molecular Formula: C20H25NO2S2·HCl
Formula Weight: 412.00
CAS Number: 145821-59-6
Purity: >98%
Formulation: Powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml), in Ethanol (up to at least 25 mg/ml) or in Water (up to at least 30 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
FXR agonist
Functions
Tiagabine is a clinically useful anticonvulsant. It is also used to treat anxiety/panic disorder and neuropathic pain. Inhibits GABA-reuptake (IC50 [3H]GABA uptake = 67 nM) via inhibiting GABA transporter 1(GAT1) blocking both neuronal and glial GABA re-uptake.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), in Ethanol (up to at least 25 mg/ml) or in Water (up to at least 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO, ethanol or distilled water may be stored at -20°C for up to 3 months.