Tribioscience ST-034307, Adenylate Cyclase 1 Inhibitor; Analgesic Activity (TBI1620)

Tribioscience ST-034307, Adenylate Cyclase 1 Inhibitor; Analgesic Activity (TBI1620)

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Product Details

Formal Name: 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one

Molecular Formula: C₁₀H₄Cl₄O₂

Formula Weight: 297.95

CAS Number: 133406-29-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml)

Storage: RT

Stability: ≥ 1 year.

Applications

Adenylate cyclase 1 inhibitor; Analgesic activity

Functions

A novel selective adenylyl cyclase 1 (AC1) inhibitor, IC₅₀=2.3 μM . Inhibits calcium²⁺-stimulated cAMP accumulation in HEK cells stably transfected with AC1. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells.  It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation. Displays analgesic properties in a mouse model of inflammatory pain.

Application Procedures

First dissolved in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.