Tribioscience RVX-208, BET Bromodomain Inhibitor (TBI1487)
Couldn't load pickup availability
Still have questions? Ask our experts!
Tribioscience RVX-208, BET Bromodomain Inhibitor (TBI1487)
Research Use Only. Not intended for human use.
Buy Tribioscience products from MSE Supplies at the best value.Â
Product Details
Formal Name:Â 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-4(3H)-quinzolinone
Molecular Formula:Â C20H22N2O5
Formula Weight:Â 370.41
CAS Number:Â 1044870-39-4
Purity:Â >98%
Formulation:Â powder
Solubility:Â Soluble in DMSO (up to 75 mg/ml) or in Ethanol (up to 4 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
BET bromodomain inhibitor
Functions
RVX-208 is a potent BET bromodomain antagonist with IC50 of 0.510 μM for BD2, with approximately 170-fold selectivity over BD1. Increases apolipoprotein A-1 and HDL cholesterol in vitro and in vivo. Reduces atherosclerosis.
Application Procedures
First dissolved in DMSO (up to 75 mg/ml) or in Ethanol (up to 4 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.