Product Details
Formal Name: 1-(2-Phenylacetyl)-L-prolyl-glycine ethyl ester
Alternate Names: SGS-111; GVS 111
Molecular Formula: C17H22N2O4
Formula Weight: 318.37
CAS Number: 157115-85-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Nootropic and neuroprotective agent
Functions
A novel proline-containing dipeptide with nootropic and cognition-enhancing activity. Rescues α-synuclein amyloid toxicity in cellular models. Stimulates the expression of NGF and BDNF in rat hippocampus. Improves viability of hippocampal HT-22 neurons in a glutamate toxicity model. Normalizes blood glucose level and tolerance to glucose load in a streptozotocin diabetic rat model of developing diabetes.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.