Product Details
Formal Name: 4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonamide
Alternate Names: JC121
Molecular Formula: C16H17ClN2O4S
Formula Weight: 368.80
CAS Number: 16673-34-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO up to 45 mg/ml
Storage: RT
Stability: ≥ 3 years.
Applications
NLRP3 inflammasome inhibitor
Functions
NLRP3 inflammasome inhibitor which likely acts via interfering with the formation of the NLRP3 inflammasome complex and which exhibits promising in vivo protective activities in mouse acute myocardial infarction models. It blocks ASC aggregation, blocks the release of IL-1β and the activation of caspase-1 in macrophages expressing constitutively active NLRP3 but does not directly inhibit caspase-1. Limits infarct size after myocardial ischemia-reperfusion as well as leukocyte infiltration in a peritonitis model in mice.
Application Procedures
First dissolved in DMSO up to 45 mg/ml, then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.