Product Details
Formal Name: (7aS,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3’,2’,1’-ij][1,6]napthyridin-10-one
Alternate Names:Â Matridin-15-one
Molecular Formula:Â C15H24N2O
Formula Weight:Â 248.36
CAS Number:Â 519-02-8
Purity:Â >98%
Formulation:Â powder
Solubility:Â Soluble in Water (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Induces RIP3 necroptosis
Functions
Matrine is a natural product found in the plant Sophora flavescens. It has been found to possess myriad biological activities including a positive inotropic effect, reduced glucose intolerance and hepatic steatosis in a mouse model via activation of HSP723, various anti-cancer effects. Matrine has also recently been shown to induce RIP3-dependent necroptosis in cholangiocarcinoma cells.
Application Procedures
First dissolved in Water (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in distilled water may be stored at -20°C for up to 3 months.