Product Details
Formal Name:Â 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine
Alternate Names:Â O6-(4-Bromothenyl)guanine
Molecular Formula:Â C10H8BrN5O3S
Formula Weight:Â 326.20
CAS Number:Â 192441-08-0
Purity:Â >98%
Formulation:Â powder
Solubility:Â Soluble in DMSO (up to 10 mg/ml with warming)
Storage: -20°C
Stability: ≥ 1 year.
Applications
MGMT inhibitor
Functions
Lomeguatrib is a potent (IC50 = 9 nM) inhibitor of O6-Methylguanine-DNA Methyltransferase (MGMT), an important DNA repair protein. It is currently being investigated in cancers that have acquired resistant to the chemotherapeutic temozolomide2-5, as well as other chemotherapeutics.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.