Product Details
Formal Name: 1,2-dithiolane-3-pentanoic acid, racemic
Alternate Names: Thioctic acid
Molecular Formula: C8H14O2S2
Formula Weight: 206.30
CAS Number: 1077-28-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 30 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Endogenous antioxidant and cofactor
Functions
alpha-Lipoic acid is an endogenous antioxidant. Treatment with alpha-lipoic acid increased hepatic nuclear Nrf2 levels, induced Nrf2-mediated gene transcription, and reversed age-related decline in hepatic glutathione levels in a rat model. It is an essential cofactor required for catalysis by multiple mitochondrial enzymes including pyruvate dehydrogenase, α-ketoglutarate dehydrogenase and branched-chain ketoacid dehydrogenase among others. It has shown efficacy as a treatment in diabetic neuropathy.
Application Procedures
First dissolved in DMSO (up to at least 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored under an inert atmosphere at -20°C for up to 1 month.