Product Details
Formal Name: 3-[8-Amino-1-(2-phenyl-7-quinolyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutanol
Alternate Names: OSI-906
Molecular Formula: C26H23N5O
Formula Weight: 421.49
CAS Number: 867160-71-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
IGF-1R kinase and InsR kinase inhibitor
Functions
Linsitinib is a potent and selective dual inhibitor of insulin-like growth factor 1 (IGF-1R) kinase and insulin receptor (InsR) kinase (IC50’s = 35 and 75 nM respectively). It has been investigated as a chemotherapeutic in combination with other drugs for various cancers.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.