First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Tribioscience Honokiol, SIRT3 Activator (TBI2311)
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Tribioscience Honokiol, SIRT3 Activator (TBI2311)
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Product Details
Formal Name: 3′,5-Diallyl-[1,1′-biphenyl]-2,4′-diol
Alternate Names: NSC-293100
Molecular Formula: C18H18O2
Formula Weight: 266.30
CAS Number: 35354-74-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
SIRT3 activator
Functions
Natural product that acts as a SIRT3 activator. It increases mitochondrial oxygen consumption and reduces ROS production in wild type but not SIRT3-KO cells. It reversed cardiac hypertrophy in mice and rescued myocardial and mitochondrial energetics in type 2 diabetic rats. It was shown to increase SIRT3 expression in the hippocampus and attenuated surgery-induced memory loss, neuronal apoptosis, neuroinflammation and oxidative damage. It increases expression of adipocyte gene markers, gene-involved lipolysis and glucose transport and in general, promotes insulin sensitivity.
Application Procedures