First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Tribioscience FH-535, Wnt/β-Catenin Inhibitor (TBI1328)
SKU: TBI1328-10MG
Tribioscience FH-535, Wnt/β-Catenin Inhibitor (TBI1328)
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Product Details
Formal Name: 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide
Molecular Formula: C13H10Cl2N2O4S
Formula Weight: 361.21
CAS Number: 108409-83-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Wnt/β-catenin inhibitor
Functions
Suppresses Wnt/β-catenin signaling. It antagonizes PPARγ and PPARδ ligand-dependent activation which is mediated by inhibition of recruitment of the coactivators β-catenin and GRIP1 but not the corepressors NCoR and SMRT1. Inhibits the migration and growth of breast cancer cell lines as well as colon, lung and liver cell lines. Useful tool for probing the involvement of Wnt signaling pathway.
Application Procedures