Tribioscience Erlotinib HCl, EGFR Kinase Inhibitor (TBI2135)

Tribioscience Erlotinib HCl, EGFR Kinase Inhibitor (TBI2135)

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Product Details

Formal Name: N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride

Molecular Formula: C₂₂H₂₃N₃O₄ · HCl

Formula Weight: 429.91

CAS Number: 183319-69-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 18 mg/ml with warming).

Storage: -20°C

Stability: ≥ 1 year.

Applications

EGFR Kinase inhibitor

Functions

Potent inhibitor of EGFR tyrosine kinase (IC50 =  2 nM). Potent inhibitor of mutant JAK2-V617F. Weaker inhibitor of ErbB-2 kinase (Ki =  1 μM) ErbB-4 kinase (Ki =  1.5 μM). HDAC inhibitors sensitize for erlotinib activity in EGFR-mutated and wildtype non-small cell lung cancer (NSCLC) cells. A clinically effective agent for NSCLC.

Application Procedures