Tribioscience Dihydroergotamine Mesylate, Serotonin Receptor Agonist (TBI3400)

Tribioscience Dihydroergotamine Mesylate, Serotonin Receptor Agonist (TBI3400)

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Product Details

Formal Name: (5’a,10a)-9,10-Dihydro-12′-hydroxy-2′-methyl-5′-(phenylmethyl)ergotaman-3′,6′,18-trione, mesylate

Molecular Formula: C₃₃H₃₇N₅O₅ • CH₃SO₃H

Formula Weight: 679.80

CAS Number: 6190-39-2

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Serotonin receptor agonist

Functions

Full agonist at serotonin 5HT1B and 5HT1D receptors, IC50= 2 and 2.2 nM respectively and also at 5HT1A and 5HT1F receptors. One of the oldest agents for treatment of migraine. Also acts as a potent vasoconstrictor and alpha-adrenergic antagonist.

Application Procedures