First dissolved in DMSO (25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Tribioscience Dihydroergotamine Mesylate, Serotonin Receptor Agonist (TBI3400)
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Tribioscience Dihydroergotamine Mesylate, Serotonin Receptor Agonist (TBI3400)
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Product Details
Formal Name: (5’a,10a)-9,10-Dihydro-12′-hydroxy-2′-methyl-5′-(phenylmethyl)ergotaman-3′,6′,18-trione, mesylate
Molecular Formula: C33H37N5O5 • CH3SO3H
Formula Weight: 679.80
CAS Number: 6190-39-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (25 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Serotonin receptor agonist
Functions
Full agonist at serotonin 5HT1B and 5HT1D receptors, IC50= 2 and 2.2 nM respectively and also at 5HT1A and 5HT1F receptors. One of the oldest agents for treatment of migraine. Also acts as a potent vasoconstrictor and alpha-adrenergic antagonist.
Application Procedures