Product Details
Formal Name: 2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone
Molecular Formula: C19H30O4
Formula Weight: 322.44
CAS Number: 55486-00-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 10 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
MPTP inhibitor
Functions
Inhibits the Ca2+ dependent mitochondrial permeability transition pore (MPTP) without inhibiting respiration. Maximum effect on Ca2+ retention capacity of rat liver mitochondria at 100 μM. Inhibits etoposide-induced apoptosis in L929 cells at 5 μM via inhibition of cytochrome c release. Delays rotenone-induced cardiac dysfunction in a zebrafish model of development and cardiovascular function. Substrate for various quinone oxidoreductases.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.