Product Detail
Formal Name: 4-(Acetylamino)-N-(2-aminophenyl)benzamide
Alternate Names: PD-123654; N-acetyl-dinaline; GOE-5549
Molecular Formula: C15H15N3O2
Formula Weight: 269.30
CAS Number: 112522-64-2
Purity: >98%
Formulation: Powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
HDAC inhibitor
Functions
Orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9, 0.9, 1.2 and >20 μM for HDAC1, HDAC2, HDAC3 and HDAC8 respectively. Mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo. Increases neuroplasticity during memory extinction. Protects beta cells from cytokine-induced apoptosis.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.