Tribioscience C-176, STING Antagonist (TBI4130)

Tribioscience C-176, STING Antagonist (TBI4130)

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Product Details

Formal Name: N-(4-Iodophenyl)-5-nitrofuran-2-carboxamide

Molecular Formula: C11H7IN2O4

Formula Weight: 358.09

CAS Number: 314054-00-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

STING antagonist

Functions

C-176 is an inhibitor of the signaling molecule STING in mouse cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. Treatment of Trex-/- mice with C-176 resulted in a significant reduction in serum levels of Type I Interferons and amelioration of systemic inflammation.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.