Product Details
Formal Name: N-[3-[[5-Iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
Molecular Formula: C23H26IN7O2S
Formula Weight: 591.47
CAS Number: 702675-74-9
Purity: >97%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Dual TBK1/IKKε inhibitor – enhances lentiviral transduction efficiency
Functions
BX795, originally described as a moderately potent inhibitor of PDK1 (IC50 = 111 nM), is, more importantly, a dual inhibitor of TBK1 and IKKε (IC50’s = 6 and 41 nM respectively). TBK1 and IKKε regulate the production of Type I interferons during bacterial and viral infection via phosphorylation of the transcription factor IRF. It also inhibited of MARK, MLK, NUAK, AurB, and ERK8.3 BX795 exhibited antitumor activity in human oral squamous cell carcinoma, pancreatic ductal adenocarcinoma, and Glioblastoma Multiforme. BX795 has been used to enhance lentiviral transduction efficiency in human NK cells and human primary T cells for CAR-T cell therapy.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.