First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Tribioscience Axitinib, VEGFR Kinase Inhibitor (TBI2118)
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Tribioscience Axitinib, VEGFR Kinase Inhibitor (TBI2118)
Research Use Only. Not intended for human use.
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Product Details
Formal Name: N-Methyl-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide
Molecular Formula: C22H18N4OS
Formula Weight: 386.47
CAS Number: 319460-85-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
VEGFR kinase inhibitor
Functions
Potent inhibitor of VEGFR-2, -3, and -1, IC50 = 0.2, 0.1-0.3, and 1.2 nM respectively displaying minimal activity against a panel of ~100 protein kinases. Inhibits angiogenesis and vascular permeability. Also inhibits BCR-ABL1 (T315I) with high potency, Ki = 149 pM for autophosphorylated ABL1 (T315I). Inhibits proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Clinically useful anticancer agent.
Application Procedures