First dissolved in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Tribioscience AT-101, Bcl-2 Inhibitor (TBI1165)
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Tribioscience AT-101, Bcl-2 Inhibitor (TBI1165)
Research Use Only. Not intended for human use.
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Product Details
Alternate Names:Â Gossypol R(-)
Molecular Formula:Â C30H30O8
Formula Weight:Â 518.56
CAS Number:Â 90141-22-3
Purity:Â >98%
Formulation:Â Powder
Solubility:Â Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Bcl-2 inhibitor
Functions
A small molecule mimic of the BH3 domain of cellular Bcl-2 inhibitors which interferes with the function of Bcl-2-family antiapoptotic proteins. Induces apoptosis in drug-resistant multiple myeloma cell lines. Apoptosis is activated by the mitochondrial pathway. Cell permeable.
Application Procedures