Tribioscience Anti-Mouse PD-1 Mouse Monoclonal Antibody (LALAPG) (TBS10218)

Description: Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor expressed on the surface of immune cells, including T cells, B cells, and myeloid cells. It plays a crucial role in immune regulation by delivering inhibitory signals upon interaction with its ligands, PD-L1 and PD-L2, to reduce T cell activity and maintain immune homeostasis. This antibody also contains a LALAPG mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors.

Applications:

• in vivo blocking of PD-1/PD-L signaling

Molecular Weight: 150 kDa

Host: Mouse

Isotype: Mouse IgG2a Kappa

Mutations: L234A L235A P329G (LALAPG)

Concentration: 4 mg/ml

Purity: >95%

Formulation: PBS, pH 7.0, no stabilizers or preservatives.

Endotoxin: < 1EU/mg

Clonality: Monoclonal

Sterility: 0.2 µm filtered

Storage: Stable at 4°C for one month. Store at -20°C for long-term storage.