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Description: IL-4Rα is a critical component of the receptor complexes for both IL-4 and IL-13, playing a significant role in immune system modulation. IL-4Rα is expressed on various cell types, including T helper type 2 (Th2) cells, mast cells, basophils, eosinophils, macrophages, dendritic cells, and endothelial cells. IL-4Rα is implicated in various conditions, including asthma, atopic dermatitis, and certain cancers. Therapeutic strategies targeting IL-4Rα, such as Dupilumab, have been developed.
Applications:
- Functional assays
Molecular Weight: 150 kDa
Host: Human
Isotype: Human IgG4 kappa
Concentration: 4 mg/ml
Purity: >95%
Formulation: PBS, pH 7.0, no stabilizers or preservatives.
Endotoxin: < 1EU/mg
Clonality: Monoclonal
Sterility: 0.2 µm filtered
Storage: Stable at 4°C for one month. Store at -20°C for long-term storage.