TMED10 Polyclonal Antibody Reactivity Human
SKU: E-AB-53096-200
TMED10 Polyclonal Antibody Reactivity Human
| SKU # | E-AB-53096 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human TMED10 |
| Abbre | TMED10 |
| Synonyms | 1110014C03Rik , 21 kDa transmembrane trafficking protein, 21 kDa transmembrane-trafficking protein, MGC102351, S31I125, S31III125, TMED 10, TMEDA, Tmed10, Tmp , Tmp 21, Tmp 21 I, p23, p24 family protein delta 1, p24 family protein delta-1, p24(DELTA), p24delta, p24delta1 |
| Swissprot | |
| Calculated MW | 25 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Golgi apparatus>cis-Golgi network membrane. Melanosome. Endoplasmic reticulum membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane. Cytoplasmic vesicle>secretory vesicle membrane. Cell membrane. Golgi apparatus>trans-Golgi network membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cycles between compartments of the early secretatory pathway. |
| Concentration | 0.9 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Neuroscience, Signal transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:50-1:200 |
Background
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.