SOX2 Monoclonal Antibody
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SOX2 Monoclonal Antibody
Product Details
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC-P |
| Synonyms | SOX2 |
| Cellular Localization | nucleus |
| Tissue Specificity | Tonsil |
| Storage | The concentrated should be stored at -20°C protecting from light,Valid for 12 months. |
| Shipping | Ice bag |
Background
The SOX2 gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors, which plays an important role in early organ development. SOX2 can be used in the auxiliary diagnosis of germ cell tumors. 90% of embryonic cancers express SOX2, but not in seminoma, yolk sac tumor and choriocarcinoma. SOX2 has been shown to be a negative prognostic factor and associated with aggressive phenotypes in breast, head and neck, gastric, colorectal and bladder cancers. In small cell lung cancers, SOX2 was also correlated with a poor prognosis. Conversely, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and was shown to be an independent positive prognostic marker.