Recombinant Mouse HVEM/TNFRSF14 Protein (Fc Tag)(Active)
SKU: PKSM040955-50
Recombinant Mouse HVEM/TNFRSF14 Protein (Fc Tag)(Active)
| SKU # | PKSM040955 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | ATAR, Atar, HVEM, Herpesvirus entry mediator, HveA, TNF receptor-like molecule, TR2, Tnfrsf14, Tumor necrosis factor receptor superfamily member 14, another TRAF-associated receptor |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Gln39-Val207 |
| Accession | Q80WM9 |
| Calculated Molecular Weight | 455 kDa |
| Observed Molecular Weight | 50-60 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Mouse Protein Tnfrsf14, is a type I transmembrane protein belonging to the TNF receptor superfamily. It is tumor necrosis factor receptor superfamily member 14 and expressed on the surface of T cells during the resting state. Interaction of HVEM with TNF family member LIGHT co-stimulates T cells and promotes inflammation. HVEM also triggers inhibitory signaling cascade in effector T (Teff) cells and regulatory T cells (Tregs) as a ligand of B and T lymphocyte attenuator. Tnfrsf14 is detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. It has demonstrated that HVEM Ig is able to exert a significant antiviral effect against HSV-1 infection in vivo.