Recombinant Mouse FCRL1 Protein (aa 1-204, His Tag)
SKU: PKSM040425-100
Recombinant Mouse FCRL1 Protein (aa 1-204, His Tag)
| SKU # | PKSM040425 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | BXMAS1-like protein 1, Bxmas1, Bxmh1, Bxmh1b, CD307a, Fc receptor homolog 1, Fc receptor-like protein 1, FcR-like protein 1, FcRH1, FcRL1, Fcrh1, Fcrh1l, Fcrh1s, IFGP family protein 1, Ifgp1 Protein, mBXMH1, mIFGP1, moFcRH1 |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Met1-Thr204 |
| Accession | Q8R4Y0-2 |
| Calculated Molecular Weight | 21.6 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Fc receptor-like protein 1, also known as FcR-like protein 1, Fc receptor homolog 1, IFGP family protein 1, Immune receptor translocation-associated protein 5 and FCRL1, is a single-pass type I membrane protein which contains threeIg-like C2-type (immunoglobulin-like) domains. It is a cell-surface membrane protein belonging to FCRL family and is preferentially expressed on B cells. FCRL1 is primarily expressed in secondary lymphoid tissues by mature subsets of B cells. It is detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. FCRL1 is specifically expressed by mature B lineage cells with higher expression in naive versus memory B cells (at protein level). Human Fc receptor-like molecules (FCRL1, FCRL2, FCRL3, FCRL4, FCRL5) have tyrosine-based immunoregulatory potential and are expressed by B-lineage subpopulations. FCRL1 may function as an activating coreceptor in B cells. It may also function in B cells activation and differentiation.