Recombinant Mouse CD32b/FCGR2B Protein (His Tag)
SKU: PKSM041016-50
Recombinant Mouse CD32b/FCGR2B Protein (His Tag)
| SKU # | PKSM041016 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD32, Fc gamma receptor IIB, Fc-gamma RII, Fc-gamma-RIIB, FcRII, Fcgr2, Fcgr2b, IgG Fc receptor II beta, Low affinity immunoglobulin gamma Fc region receptor II, Ly-17, Lymphocyte antigen 17 |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Thr30-Pro210 |
| Accession | P08101 |
| Calculated Molecular Weight | 21.6 kDa |
| Observed Molecular Weight | 33 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target formonoclonal antibody therapy for malignancies.