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Recombinant Macaca nemestrina PCSK9/Proprotein Convertase 9 Protein (His Tag)
SKU: PKSQ050064-50
Recombinant Macaca nemestrina PCSK9/Proprotein Convertase 9 Protein (His Tag)
| SKU # | PKSQ050064 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | PC9, PCSK9, Proprotein Convertase 9, Proprotein Convertase Subtilisin/Kexin Type 9, Subtilisin/Kexin-Like Protease PC9 |
| Species | Macaca nemestrina |
| Expression Host | HEK293 Cells |
| Sequence | Gln31-Gln152&Ser153-Gln692 |
| Accession | A8T662 |
| Calculated Molecular Weight | 14&59 kDa |
| Observed Molecular Weight | 16-21&55-77 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 0.1M Arg, 0.1M Glu, 20% glycerol, 0.01% tween20, 5% Trehalose, pH 6.0. |
| Reconstitution | Not Applicable |
Background
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development.