Recombinant Human Tumor-associated Calcium Signal Transducer 2/TROP-2 (C-Avi-6His) Biotinylated
SKU: PKSH034007-100
Recombinant Human Tumor-associated Calcium Signal Transducer 2/TROP-2 (C-Avi-6His) Biotinylated
| SKU # | PKSH034007 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Cell surface glycoprotein Trop-2, Membrane component chromosome 1 surface marker 1, TACSTD2, TROP2, Tumor-associated calcium signal transducer 2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | His27-Thr274 |
| Accession | P09758 |
| Calculated Molecular Weight | 30.5 kDa |
| Observed Molecular Weight | 40-60 kDa |
| Tag | C-Avi-His |
| Bio-activity | Immobilized Biotinylated Human TROP-2-Avi-His at 1μg/ml (100 μl/well) can bind Anti-Human TROP-2 mAb.The ED50 of Anti-Human TROP-2 mAb s 4.19 ng/ml. |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Tumor associated calcium signal transducer 2 (TACSTD2, TROP-2) is a type I cell surface glycoprotein that is highly expressed on human carcinomas. It was originally identified as an antigen present on human gastrointestinal tumors and is the second of two members of this family. Human and mouse TROP-2 share 87% amino acid (aa) similarity. TROP-2 is capable of transducing an intracellular calcium signal and may play a role in tumor growth. It also has adhesive functions.