Recombinant Human PGD Protein (Human Cells, His Tag)
SKU: PKSH033424-50
Recombinant Human PGD Protein (Human Cells, His Tag)
| SKU # | PKSH033424 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | 6-phosphogluconate dehydrogenase, 6PGD, Decarboxylating, PGD, PGDH |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Ala483 |
| Accession | P52209 |
| Calculated Molecular Weight | 54.2 kDa |
| Observed Molecular Weight | 58 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Reconstitution | Not Applicable |
Background
6-phosphogluconate dehydrogenase(PGD) is a cytoplasm-located protein; and belongs to the 6-phosphogluconate dehydrogenase family. 6PGD is the second dehydrogenase in the pentose phosphate shunt. It catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2; with concomitant reduction of NADP to NADPH. Mutations within the gene coding this enzyme result in 6-phosphogluconate dehydrogenase deficiency; an autosomal hereditary disease effecting the red blood cells.