Recombinant Human LMCD1/Dyxin Protein (His Tag)
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Recombinant Human LMCD1/Dyxin Protein (His Tag)
| SKU # | PKSH032706 |
| Expression Host | E.coli |
Description
| Synonyms | Dyxin, LIM and cysteine-rich domains protein 1, LMCD1 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Ser365 |
| Accession | Q9NZU5 |
| Calculated Molecular Weight | 44.0 kDa |
| Observed Molecular Weight | 45 kDa |
| Tag | N-His & C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, pH 8.0. |
| Reconstitution | Not Applicable |
Background
LMCD1 is transcriptional cofactor which contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region. It also has several potential phosphorylation and N-myristoylation sites and a single potential N-glycosylation site. LMCD1 is expressed in many tissues with highest abundance in skeletal muscle. LMCD1 restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. It plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.