PTPRN Polyclonal Antibody Reactivity Human
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PTPRN Polyclonal Antibody Reactivity Human
| SKU # | E-AB-52202 |
| Reactivity |
Human, Mouse, Rat |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human PTPRN |
| Abbre | PTPRN |
| Synonyms | CA 512, FLJ16131, IA 2, IA 2/PTP, IA2, IA2/PTP, ICA 3, ICA 512, ICA3, ICA512, Islet cell antigen 2, Islet cell antigen 512, Islet cell autoantigen 3, Protein tyrosine phosphatase like N, Protein tyrosine phosphatase like N precursor, Protein tyrosine phosphatase recepto |
| Swissprot | |
| Cellular Localization | Membrane. Neuroendocrine secretory granules. |
| Concentration | 0.96 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Metabolism, Neuroscience, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:200 |
Background
IA-2/PTPRN is a member of the protein tyrosine phosphatase (PTP) family,which contains a transmembrane region,an intracellular PTP-like domain and an extracellular N-terminus. Experiments found that IA-2/PTPRN localizes to secretory granules and is exclusively expressed in neuroendocrine cells (including pancreatic islets cell). IA-2/PTPRNwas found to be a major autoantigen in insulin-dependent diabetes mellitus and the detection of autoantibodies against IA-2/PTPRN is commonly used as a diabetes diagnosis marker.