PTCH1 Polyclonal Antibody Reactivity Human, Mouse
SKU: E-AB-10571-200
PTCH1 Polyclonal Antibody Reactivity Human, Mouse
| SKU # | E-AB-10571 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human PTCH1 |
| Abbre | PTCH1 |
| Synonyms | BCNS, HPE7, NBCCS, PTC, PTC1, PTCH, PTCH11 |
| Swissprot | |
| Calculated MW | 161 kDa |
| Cellular Localization | Nucleus, Plasma Membrane, caveola, ciliary membrane, plasma membrane, Other locations: axonal growth cone, dendritic growth cone, endocytic vesicle membrane, integral component of membrane, intracellular membrane-bounded organelle, midbody, perinuclear region of cytoplasm, postsynaptic density. |
| Concentration | 0.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Neuroscience, Stem Cells |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:50-1:200 |
Background
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.