PPP1R12A Polyclonal Antibody Store at -20°C
SKU: E-AB-11418-200
PPP1R12A Polyclonal Antibody Store at -20°C
| SKU # | E-AB-11418 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human PPP1R12A |
| Abbre | PPP1R12A |
| Synonyms | M130, MBS, MYPT1, Myosin binding subunit, Myosin phosphatase target subunit 1, Myosin phosphatase targeting subunit 1, Myosin phosphatase-targeting subunit 1, PPP1R12A, Protein phosphatase 1 regulatory , Protein phosphatase 1 regulatory inhibitor subunit 12A |
| Swissprot | |
| Calculated MW | 115 kDa |
| Cellular Localization | Cytoplasm. Along actomyosin filaments and stress fibers. |
| Concentration | 0.4 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:200-1:1000 |
Background
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC.