PLAT Polyclonal Antibody
SKU: E-AB-12879-200
PLAT Polyclonal Antibody
| SKU # | E-AB-12879 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human PLAT |
| Abbre | PLAT |
| Synonyms | Alteplase, DKFZp686I03148, PLAT, Plasminogen activator tissue, Plasminogen activator tissue type, Reteplase, T Plasminogen Activator, T-plasminogen activator, Tissue plasminogen activator (t PA), Tissue type plasminogen activator, Tissue-type plasminogen, t PA, t-PA |
| Swissprot | |
| Calculated MW | 63 kDa |
| Cellular Localization | Secreted>extracellular space. |
| Concentration | 0.4 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Cardiovascular, Metabolism |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:200-1:1000 |
| IHC | 1:50-1:200 |
Background
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.