PIM1 Polyclonal Antibody Store at -20°C
SKU: E-AB-14694-200
PIM1 Polyclonal Antibody Store at -20°C
| SKU # | E-AB-14694 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human PIM1 |
| Abbre | PIM1 |
| Synonyms | Oncogene PIM 1, Oncogene PIM1, PIM, PIM 1, PIM1, PIM3, Pim 1 kinase, Pim 1 oncogene, Pim2, Proto oncogene serine/threonine protein kinase Pim 1, Proto-oncogene , pim 1 kinase 44 kDa isoform, pim 1 oncogene (proviral integration site 1), pim1 kinase 44 kDa isoform |
| Swissprot | |
| Cellular Localization | Cytoplasm. Nucleus and Cell membrane. |
| Concentration | 0.4 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Signal Transduction, Stem Cells |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:200 |
Background
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons.