Phospho-JAK3 (Tyr785) Polyclonal Antibody
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Phospho-JAK3 (Tyr785) Polyclonal Antibody
| SKU # | E-AB-21215 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IHC-p |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC-p |
| Clonality | Polyclonal |
| Immunogen | Synthesized peptide derived from human JAK3 around the phosphorylation site of Tyr785 |
| Synonyms | EC 2.7.10.2, JAK 3, JAK L, JAK-3, JAK3, JAK3 HUMAN, JAKL, Jak3, Janus Kinase3, Janus kinase 3, Janus kinase 3 (a protein tyrosine kinase, L JAK, L-JAK, LJAK, Leukocyte janus kinase, Protein tyrosine kinase leukocyte, Tyrosine protein kinase JAK3, Tyrosine-prote, leukocyte) |
| Swissprot | |
| Calculated MW | 125 kDa |
| Observed MW | 125 kDa |
| Cellular Localization | Endomembrane system. Wholly intracellular, possibly membrane associated. |
| Tissue Specificity | In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:100-1:300 |
Background
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).