Phospho-CXCR4 (Ser339) Polyclonal Antibody
SKU: E-AB-21282-200
Phospho-CXCR4 (Ser339) Polyclonal Antibody
| SKU # | E-AB-21282 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Host | Rabbit |
| Applications | WB, IHC-p, IF |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat, Monkey |
| Applications | WB, IHC-p, IF |
| Clonality | Polyclonal |
| Immunogen | Synthesized peptide derived from human Fusin around the phosphorylation site of Ser339 |
| Synonyms | C-X-C chemokine receptor type 4, CD184, CD184 antigen, CXC-R4, CXCR-4, CXCR4, Chemokine (C X C motif) receptor 4, Chemokine CXC Motif Receptor 4, D2S201E, FB22, Fusin, HM89, HSY3RR, LAP 3, LAP3, LCR1, LESTR, Leuk, Leukocyte derived seven transmembrane domain receptor |
| Swissprot | |
| Calculated MW | 40 kDa |
| Observed MW | 38 kDa |
| Cellular Localization | Cell membrane. In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. |
| Tissue Specificity | Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Metabolism, Immunology, Microbiology, Neuroscience, Stem Cells |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:100-1:300 |
| IF | 1:200-1:1000 |
Background
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1.The protein has 7 transmembrane regions and is located on the cell surface.It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells.Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome.Alternate transcriptional splice variants, encoding different isoforms, have been characterized.