p70 S6 Kinase Alpha Monoclonal Antibody
SKU: E-AB-22198-200
p70 S6 Kinase Alpha Monoclonal Antibody
| SKU # | E-AB-22198 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Applications | IHC-p |
Product Details
| Isotype | IgG |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC-p |
| Clonality | Monoclonal |
| Immunogen | Recombinant Protein of P70 S6 Kinase of RPS6KB1 |
| Abbre | p70 S6 kinase alpha |
| Synonyms | 70 kDa ribosomal protein S6 kinase 1, KS6B1, P70 S6 Kinase, P70 beta 1, alpha 1, alpha 2, p70 S6 kinase, p70 S6 kinase alpha, p70 S6K, p70 S6K-alpha, p70 S6KA, p70 alpha, p70 ribosomal S6 kinase alpha, p70 ribosomal S6 kinase beta 1, p70(S6, p70(S6K) alpha |
| Swissprot | |
| Cellular Localization | Cytoplasm, Nucleus, Cytoplasm and Cell junction>synapse>synaptosome, Mitochondrion outer membrane. |
| Tissue Specificity | Widely expressed |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Protein A purification |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction |
| Clone No. | 1C7 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:100-200 |
Background
P70 S6 Kinase alpha is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and contains 2 non-identical kinase catalytic domains. It phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein is activated by serine/threonine phosphorylation and protein kinase C and inactivated by type 2A phosphatase. Activation leads to an increase in protein synthesis and cell proliferation. Overexpression of this kinase is involved in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.