NEDD9 Polyclonal Antibody Store at -20°C
SKU: E-AB-15091-200
NEDD9 Polyclonal Antibody Store at -20°C
| SKU # | E-AB-15091 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human NEDD9 |
| Abbre | NEDD9 |
| Synonyms | CAS-L, CAS2, CASL, CASS2, CRK-associated substrate-related protein, Cas like docking, Cas scaffolding protein family member 2, CasL, Crk associated substrate related, Crk associated substrate related protein, dJ49G10.2, dJ49G10.2 (Enhancer of Filamentation 1 (HEF1)) |
| Swissprot | |
| Calculated MW | 93 kDa |
| Cellular Localization | Cytoplasm>cytoskeleton>spindle and Cytoplasm>cell cortex. Nucleus. Golgi apparatus. Cell projection>lamellipodium. Cytoplasm. Cell junction>focal adhesion. Localizes to both the cell nucleus and the cell periphery and is differently localized in fibroblasts and epithelial cells. In fibroblasts is predominantly nuclear and in some cells is present in the Golgi apparatus. In epithelial cells localized predominantly in the cell periphery with particular concentration in lamellipodia but is also found in the nucleus. Isoforms p105 and p115 are predominantly cytoplasmic and associate with focal adhesions while p55 associates with mitotic spindle. |
| Concentration | 0.4 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:200-1:1000 |
Background
The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants.