NBR1 Monoclonal Antibody
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NBR1 Monoclonal Antibody
| SKU # | E-AB-22148 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Applications | IHC-p, IF |
Product Details
| Isotype | IgG |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC-p, IF |
| Clonality | Monoclonal |
| Immunogen | Recombinant Protein of NBR1 |
| Abbre | NBR1 |
| Synonyms | 1A1 3B, 1A13B, B box protein, Cell migration-inducing gene 19 protein, KIAA0049, M17S2, MIG 19, MIG19, Membrane component, Membrane component chromosome 17 surface marker 2, Migration inducing protein, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125) |
| Swissprot | |
| Cellular Localization | Cytoplasm. Cytoplasmic vesicle>autophagosome. Lysosome. Cytoplasm>myofibril>sarcomere>M line. In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Protein A purification |
| Research Areas | Cancer, Cell Biology |
| Clone No. | 4C6 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-300 |
| IF | 1:50-1:200 |
Background
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants.NBR1 (NBR1, Autophagy Cargo Receptor) is a Protein Coding gene. Diseases associated with NBR1 include Inclusion Body Myositis and Synucleinopathy. Among its related pathways are Mitophagy - animal. GO annotations related to this gene include ubiquitin binding and mitogen-activated protein kinase binding.