MSE PRO 2-(Dicyclohexylphosphino)-3, 6-dimethoxy-2'-4'-6'-tri-i-propyl-1, 1'-biphenyl (BrettPhos), 98% Purity

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MSE PRO™ 2-(Dicyclohexylphosphino)-3, 6-dimethoxy-2'-4'-6'-tri-i-propyl-1, 1'-biphenyl (BrettPhos), 98% Purity

MSE PRO™ 2-(Dicyclohexylphosphino)-3, 6-dimethoxy-2'-4'-6'-tri-i-propyl-1, 1'-biphenyl (BrettPhos) is a versatile ligand for many cross-coupling reactions at low catalyst loading such as Suziki-Miyaura coupling of tosylates and mesylates, palladium-catalyzed trifluoromethylation of aryl chlorides, nickel-catalyzed cross-coupling of styrenyl epoxides with boronic acids, etc.

MSE Supplies offers various catalysts and ligands of coupling reaction. Please contact us for customization or bulk orders.

Technical Specifications:

CAS No.	1070663-78-3
MDL No.	MFCD11973797
Chemical name	2-(Dicyclohexylphosphino)-3, 6-dimethoxy-2'-4'-6'-tri-i-propyl-1, 1'-biphenyl
Synonym(s)	BrettPhos 2-Dicyclohexylphosphino-2',4',6'-triisopropyl-3,6-diMethoxybiphenyl
Molecular formula	C₃₅H₅₃O₂P
Pack size	5 g (CM1305); 10 g (CM1306) 25 g (CM1307); 100 g (CM1308)
Molecular weight	536.77 g/mol
Purity	98 %
Melting point	191-193 °C
Solubility	Chloroform (slightly), methanol (slightly, sonicated)
Appearance	White solid
Storage	Refrigerator, under inert atmosphere

References:

[1] Rangarajan, T. M., Singh, R., Brahma, R., Devi, K., Singh, R. P., Singh, R. P., & Prasad, A. K. (2014). BrettPhos Ligand Supported Palladium‐Catalyzed C-O Bond Formation through an Electronic Pathway of Reductive Elimination: Fluoroalkoxylation of Activated Aryl Halides. Chemistry–A European Journal, 20(44), 14218-14225.

[2] Rangarajan, T. M., Brahma, R., Prasad, A. K., Verma, A. K., & Singh, R. P. (2015). Mild and efficient palladium/BrettPhos-catalyzed methoxylation and deuteriomethoxylation of activated aryl bromides. Tetrahedron letters, 56(17), 2234-2237.