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MSE PRO 2-Dicyclohexylphosphino-2', 6'-dimethoxybiphenyl (SPhos), 98% Purity - MSE Supplies LLC

MSE PRO 2-Dicyclohexylphosphino-2', 6'-dimethoxybiphenyl (SPhos), 98% Purity

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MSE PRO™ 2-Dicyclohexylphosphino-2', 6'-dimethoxybiphenyl (SPhos), 98% Purity

MSE PRO™ [2-Dicyclohexylphosphino-2′, 6′-dimethoxybiphenyl] (SPhos) is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions. Additionally, SPhos is a catalyst that is used in the preparation of thiadiazoles as DGAT1 inhibitors with potential in metabolic diseases treatment.

MSE Supplies offers various catalysts and ligands of coupling reaction. Please contact us for customization or bulk orders.

Technical Specifications:

CAS No. 657408-07-6
EC No. 613-838-2
Chemical name 2-Dicyclohexylphosphino-2', 6'-dimethoxybiphenyl
Synonym(s)
  • SPhos
  • 2-Dicyclohexylphosphino-2',6'-diMethoxy-1,1'-biphenyl
Chemical formula C26H35O2P
Pack size

25 g (CM1301)

100 g (CM1302)
Molecular weight 410.53 g/mol
Purity 98 %
Melting point 164-166 °C
Solubility
 		Soluble in chloroform
Appearance White solid
Storage temperature Inert atmosphere, room temperature

References:

[1] Kozuch, S., & Martin, J. M. (2011). What makes for a good catalytic cycle? A theoretical study of the SPhos ligand in the Suzuki–Miyaura reaction. Chemical communications, 47(17), 4935-4937.

[2] Prieto, M., Mayor, S., Lloyd-Williams, P., & Giralt, E. (2009). Use of the SPhos ligand to suppress racemization in arylpinacolboronate ester Suzuki couplings involving α-amino acids. Synthesis of biaryl derivatives of 4-hydroxyphenylglycine, tyrosine, and tryptophan. The Journal of Organic Chemistry, 74(23), 9202-9205.