MSE PRO 2-(Di-1-adaMantylphosphino)-3, 6-diMethoxy-2', 4', 6'-tri-i-propyl-1, 1'-biphenyl (AdBrettPhos), 97% Purity

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MSE PRO™ 2-(Di-1-adaMantylphosphino)-3, 6-diMethoxy-2', 4', 6'-tri-i-propyl-1, 1'-biphenyl (AdBrettPhos), 97% Purity

MSE PRO™ 2-(Di-1-adaMantylphosphino)-3, 6-diMethoxy-2', 4', 6'-tri-i-propyl-1, 1'-biphenyl (AdBrettPhos) is a bidentate phosphine ligand that has been used in various palladium-catalyzed cross-coupling reactions. The rigid, bulky structure of AdBrettPhos can help stabilize the active metal catalyst and influence the selectivity of cross-coupling reactions. Additionally, the combination of steric bulk and electronic properties makes AdBrettPhos a versatile ligand that can facilitate important organic transformations in transition metal catalysis.

MSE Supplies offers various catalysts and ligands of coupling reaction. Please contact us for customization or bulk orders.

Technical Specifications:

CAS No.	1160861-59-5
Chemical name	2-(Di-1-adaMantylphosphino)-3, 6-diMethoxy-2', 4', 6'-tri-i-propyl-1, 1'-biphenyl
Synonym(s)	AdBrettPhos bis(1-adamantyl)-[3,6-dimethoxy-2-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphane
Molecular formula	C₄₃H₆₁O₂P
Pack size	500 mg (CM1342); 1 g (CM1343)
Molecular weight	640.92 g/mol
Purity	97 %
Melting point	231-235 °C
Appearance	White to off-white solid
Storage	2-8 °C, protect from light, stored under nitrogen

References:

[1] Xue, B., Shen, J., Manna, S., Doppiu, A., & Gooßen, L. J. (2023). Selective Monoarylation of Ammonium Triflate with Aryl Chlorides Catalyzed by [Pd (β‐MeNAP) Br] 2 and AdBrettPhos. Advanced Synthesis & Catalysis, 365(20), 3473-3477.

[2] Lee, H. G., Milner, P. J., & Buchwald, S. L. (2013). An improved catalyst system for the Pd-catalyzed fluorination of (hetero) aryl triflates. Organic letters, 15(21), 5602-5605.